To help investigators navigate the unique methodological, statistical, and ethical challenges inherent to clinical and translational research, CTSI’s Consultation Services gives investigators at UCSF and affiliates the expert advice they need to produce research of the highest scientific standards.
Through this easy-to-access, comprehensive, and integrated service, researchers are connected with consultants who offer help with topics ranging from study design and biostatistics to community engagement and regulatory knowledge.
Tropical parasite expert and pathologist Conor Caffrey, PhD, has a dream: to make testing for the debilitating schistosomiasis infection, epidemic in many poor nations, as easy as getting an over-the-counter stick pregnancy test.
As a recipient of CTSI’s Catalyst Award, which links scientists with industry leaders, business experts, and venture capitalists to support the development of early-stage ideas, Caffrey is receiving critical support that is moving him closer to realizing his goal.
CTSI's Clinical and Translational Science Training (CTST) program offers research education programs, as well as level- and discipline-specific training, designed to equip the next generation of clinical and translational researchers. This specialized training supports investigators at all levels and at all four UCSF schools—Dentistry, Medicine, Nursing, and Pharmacy.
Among the educational opportunities is the Training in Clinical Research (TICR) program, which includes a Summer Clinical Research Workshop, a one-year Advanced Training in Clinical Research Program, and a two-year Master’s Degree Program.
Steven Deeks, MD, is among a team of leading HIV-AIDS researchers at UCSF working on a major national study to monitor the long-term consequences of treating HIV patients with highly active antiretroviral therapy.
CTSI’s Clinical Research Services not only enables the processing of huge volumes of samples for this significant study, but provides resources and services that make it possible for Deeks to secure further funding. He intends to use this additional support to develop a strategy for eradicating HIV from the body.
Through its Community Engagement and Health Policy program, CTSI has joined forces with public, non-profit, and private partners to launch the San Francisco Health Improvement Partnerships (SF HIP), an innovative and collaborative effort to make a measurable impact on health in the Bay Area, beginning with San Francisco.
SF HIP focuses on specific health issues identified and prioritized by community health assessments including physical activity and nutrition, alcohol abuse, Hepatitis B, children's oral health, and violence prevention.
In a commentary featured in Nature Medicine, CTSI Director Clay Johnston joins UCSF Chancellor Susan Desmond-Hellmann and UCSF Professor of Neurology Stephen Hauser in calling for improved cooperation between medical institutions, industry, and the public.
They contend that new models of collaboration will ensure an accelerated pace of discovery and interventions, and thus improve public health.
The five University of California (UC) medical campuses, in collaboration with the UC Office of the President, have established a system-wide collaboration in biomedical research to enhance clinical and translational science.
The University of California Biomedical Research Acceleration, Integration, and Development (UC BRAID) program was created to help identify shared challenges and develop solutions in the form of policy changes, new infrastructure, standard metrics, and improved processes.
The Clinical and Translational Science Awards (CTSA), established in 2006 by the National Institutes of Health, brings together resources and expertise from 60 of America’s leading biomedical institutions in an effort to transform the research environment and improve health.
This collaboration allows CTSI to do better work at UCSF by taking the best of what the national consortium can provide and implementing those best practices and solutions. It also provides the opportunity for CTSI to amplify its successes and the best models of its work on a national scale.
CTSI supports researchers from UCSF and its affiliates who are advancing science and making ground-breaking discoveries in a wide range of fields.
This evidence of translational science in action is found in publications by UCSF investigators featured in leading medical and scientific journals such as The Journal of the American Medical Association, Nature, The New England Journal of Medicine, PLoS One, and Science.
In research designed to improve the detection and treatment of a rare condition in infants known as Severe Combined Immunodeficiency (SCID), UCSF researcher Jennifer Puck, MD, launched a successful pilot program that led to legislation to change the way newborns in California are screened for this deadly disorder.
Dr. Puck and her team received research assistance from CTSI’s Clinical Research Services, which has supported more than 1,500 investigators with a wide range of resources and services available at 8 clinical sites throughout the San Francisco Bay Area.
One of the most significant challenges facing clinical researchers is the failure to recruit study participants. To help investigators overcome this obstacle, CTSI created UCSF’s first-ever centralized Participant Recruitment Service, which provides expertise, tools, and resources to facilitate enrollment of study volunteers.
Studies show that more than 80% of clinical trials are delayed due to recruitment problems. In cancer research in particular, only 50% of 6,500 cancer trials reached the minimum enrollment required for statistical significance, and one in five failed to enroll a single participant.
In research launched by a CTSI career development award, UCSF’s Kirsten Bibbins-Domingo, MD, PhD, and her team discovered that by reducing salt intake by only 3 grams per day—the equivalent of half a teaspoon—the U.S. could prevent approximately 100,000 heart attacks and as many deaths each year, and save $24 billion in health care costs annually.
Dr. Bibbins-Domingo also estimates that for every dollar spent to achieve population-wide reductions in dietary salt, up to 7 dollars could be saved in healthcare costs.
Explore the wide range of viewpoints and voices—from affiliates and partners to UCSF faculty and staff—that make up the CTSI community. Read, watch, and stay connected to learn more about how CTSI is accelerating research to improve health, and add your voice as well.