UC BRAID Weaves Network of Successful Strategies with Goal of Improving Health

The University of California Biomedical Research Acceleration, Integration and Development (UC BRAID) progress continued in the first half of 2017. These included demonstrations of collaboration, improvements in clinical research processes and a new research partnership with Stanford University. The advances are part of collaborative efforts to accelerate the translation of scientific discoveries to better health.

“UC BRAID continues to build effective collaborations and networks, which are vital for developing the resources which enhance clinical and translational research,” said Jennifer Grandis, MD, UC BRAID Executive Committee member and director of the UC San Francisco Clinical and Translational Science Institute.

UC BRAID is a consortium of five UC campuses – Davis, Irvine, Los Angeles, San Diego, and San Francisco – that have received Clinical and Translational Science Awards (CTSAs) from the National Center for Advancing Translational Sciences (NCATS) at the National Institutes of Health (NIH). .

Recent UC BRAID highlights include:

  • Publication of a study in Research Management Review that examined turnaround time for contract negotiations with industry sponsors, demonstrating the effectiveness of master agreements, among other revealing outcomes.
  • Publication of an article in the Journal of Clinical and Translational Science that defined and assessed key metrics for Institutional Review Board (IRB) efficiency, setting the stage for quality  improvement across the five campuses.
  • BRAID Program Manager Nate Buscher and Director Rachael Sak are Ambassadors for the NCATS-funded SMART IRB initiative that aims to prepare organizations for the upcoming NIH single IRB requirement. Buscher and Sak lead nationwide teams to provide guidance on charging models for single IRB review and delineate institutional and IRB responsibilities.
  • The University of California Center for Accelerated Innovation, a collaborative initiative funded by NHLBI, is now almost four years old. The Center has reviewed more than 250 proposals and funded 24 projects to advance early-stage treatments for patients through funding, training and mentorship.
  • The Drug, Device, Discovery & Development workgroup, led by Dr. Cathy Tralau-Stewart, was awarded $2.2 million to fund a new University of California Drug Discovery Consortium. The initiative will assist researchers in the creation of drugs to address important unmet medical needs.
  • Three Administrative Supplements to Enhance Network Capacity awarded by NCATS are entering their second year.
  • Leslie Yuan, CIO of UC San Francisco’s CTSI, is leading two projects based on established products at UCSF; both a UC-wide clinical trial finder and a UC-wide PI finder have agreement for adoption at all 5 UC health campuses.
  • Dr. Arash Naeim, CMO for Clinical Research at UC Los Angeles is validating and piloting a three-tiered consenting process, allowing for a universal approach across the 5 UC health campuses for biobanking of remnant tissue.
  • Dr. Douglas Bell, Director, Biomedical Informatics, UCLA CTSI, will assess the tradeoffs in effort, data completeness and accuracy when data for translational research is obtained from a multi-institutional warehouse as compared with obtaining data from each institution individually.
  • UC BRAID launched a participant recruitment workgroup made up of representatives from the five UC CTSA hubs, plus UC Riverside and Stanford University to collaborate on the development of tools, services, and strategies for increasing clinical trial participation.
  • UC BRAID formed a partnership with Stanford University  in the quest to accelerate research that improves health in California and beyond. This partnership leverages institutional infrastructure and expertise while amplifying the impact of federal and other public and private funding.
  • UC BRAID’s 8th Annual Retreat will be held in October at the UCLA Luskin Center. The theme for this year is “Translating Discovery to Health: Supporting a Learning Health System Environment”.